Istradefylline 40 mg/working day improved peak amounts and AUC of CYP3A4 substrates in scientific trials. This impact wasn't noticed with istradefylline twenty mg/day. Consider dose reduction of delicate CYP3A4 substrates.Mainly because CYP3A4 inhibition elevates ergotamine and caffeine serum ranges, the risk for vasospasm resulting in cerebral isc